Quantitative imaging of the clearance systems in the eye and the brain.

Selected Publications

Journal of Magnetic Resonance Imaging (in press)

Role of structural, metabolic, and functional MRI in monitoring visual system impairment and recovery

JR Sims, AM Chen, Z Sun, W Deng, NA Colwell, MK Colbert, J Zhu, A Sainulabdeen, MA Faiq, JW Bang, KC Chan.

Quantitative Imaging in Medicine and Surgery, 2020; 10(1):1-14

Quantitative imaging of the clearance systems in the eye and the brain

W Deng, C Liu, C Parra, JR Sims, MA Faiq, A Sainulabdeen, H Song, KC Chan

Progress in Retinal and Eye Research, 2019; 72:100767

Cholinergic nervous system and glaucoma: From basic science to clinical applications

MA Faiq, G Wollstein, JS Schuman, KC Chan.

Scientific Reports, 2019; 9: 14168

Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

V Trivedi, JW Bang, C Parra, MK Colbert, C O’Connell, A Arshad, MA Faiq, IP Conner, MS Redfern, G Wollstein, JS Schuman, R Cham, KC Chan.

Acta Biomaterialia 2019; 94: 219-231.

Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma

KC Chan, Y Yu, SH Ng, HK Mak, YW Yip, Y van der Merwe, T Ren, JS Yung, S Biswas, X Cao, Y Chau, CK Leung.

Frontiers in Neural Circuits, 2019; 13:35

Applications of manganese-enhanced magnetic resonance imaging in ophthalmology and visual neuroscience

W Deng, MA Faiq, C Liu, V Adi, KC Chan.

Neural Regeneration Research, 2019; 14(3):446-449

In vivo imaging of structural, metabolic and functional brain changes in glaucoma

A Kasi, MA Faiq, KC Chan.

Scientific Reports 2018; 8:4643.

Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma

XL Yang, Y van der Merwe, J Sim, C Parra, LC Ho, JS Schuman, G Wollstein, KL Lathrop, KC Chan.

Scientific Reports, 2017; 7:43124

Longitudinal assessments of normal and perilesional tissues in focal brain ischemia and partial optic nerve injury with manganese-enhanced MRI

KC Chan, SS Liu, Y van der Merwe, IY Zhou, SJ Fan, VK Hung, SK Chung, WT Wu, KF So, EX Wu

Experimental Eye Research 2017; 160:85–95

Whole-globe biomechanics using high-field MRI

AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, KC Chan*, IA Sigal* (*Co-corresponding authors)

Scientific Reports, 2016; 6:32080.

Non-invasive MRI assessments of tissue microstructures and macromolecules in the eye upon biomechanical or biochemical modulation

LC Ho, IA Sigal, NJ Jan, XL Yang, Y van der Merwe, Y Yu, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman, KC Chan.

Scientific Reports, 2016; 6:31464.

Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma

MC Murphy, IP Conner, C Teng, JD Lawrence, Z Safiullah, B Wang, RA Bilonick, SG Kim, G Wollstein, JS Schuman, KC Chan.

NeuroImage, 2016:125:932-40

Top-down influence on the visual cortex of the blind during sensory substitution

MC Murphy, AC Nau, C Fisher, SG Kim, JS Schuman, KC Chan.

Neural Regeneration Research, 2015; 10(11):1717-19.

Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans

AC Nau, MC Murphy, KC Chan.

Investigative Ophthalmology & Visual Science, 2015; 56(6): 3788-3800.

In vivo evaluation of white matter integrity and anterograde transport in visual system after excitotoxic retinal injury with multimodal MRI and OCT

LC Ho, B Wang, IP Conner, Y van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman, KC Chan.

Investigative Ophthalmology & Visual Science, 2014;55(9):5662-72.

Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading

LC Ho, IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman, KC Chan.

Investigative Ophthalmology & Visual Science, 2014;55(6):3747-57.

In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI

LC Ho, IP Conner, CW Do, SG Kim, EX Wu, G Wollstein, JS Schuman, KC Chan.