
Quantitative imaging of the clearance systems in the eye and the brain.
Quantitative Imaging in Medicine and Surgery, 2020; 10(1):1-14

The Neuroscientist (in press)
Visual plasticity in adulthood: Perspectives from Hebbian and homeostatic plasticity
JW Bang, G Hamilton-Fletcher, KC Chan
Biology, 2022; 11(3): 454
Advanced Diffusion MRI of the Visual System in Glaucoma: From Experimental Animal Models to Humans
M Mendoza, M Shotbolt, MA Faiq, C Parra, KC Chan
In vivo MRI evaluation of anterograde manganese transport along the visual pathway following whole eye transplantation
C Komatsu, Y van der Merwe, L He, A Kasi, JR Sims, MR Miller, IA Rosner, AA Su, JS Schuman, KM Washington, KC Chan
Neural Regeneration Research, 2022; 17(5):937-947
Glymphatic imaging and modulation in the optic nerve
A Kasi, C Liu, MA Faiq, KC Chan
Neurotherapeutics, 2021; 18: 1339–1359
Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control
Y van der Merwe, MC Murphy, JR Sims, MA Faiq, XL Yang, LC Ho, IP Conner, Y Yu, CK Leung, G Wollstein, JS Schuman, KC Chan
Frontiers in Medicine 2021; 8:681169
Oral scutellarin treatment ameliorates retinal thinning and visual deficits in experimental glaucoma
J Zhu, A Sainulabdeen, K Akers, V Adi, JR Sims, E Yarsky, Y Yan, Y Yu, H Ishikawa, CK Leung, G Wollstein, JS Schuman, W Wei, KC Chan
Investigative Ophthalmology & Visual Science, 2021; 62(10): 21
Diffusion tensor imaging of visual pathway abnormalities in five glaucoma animal models
MK Colbert, LC Ho, Y van der Merwe, XL Yang, GJ McLellan, SA Hurley, AS Field, H Yun, Y Du, JH Fingert, C Parra, MA Faiq, G Wollstein, JS Schuman, KC Chan.
Journal of Magnetic Resonance Imaging, 2021; 54:1706–1729
Role of structural, metabolic, and functional MRI in monitoring visual system impairment and recovery
JR Sims, AM Chen, Z Sun, W Deng, NA Colwell, MK Colbert, J Zhu, A Sainulabdeen, MA Faiq, JW Bang, KC Chan.
Scientific Reports, 2021; 11: 15513
In vivo MRI evaluation of early postnatal development in normal and impaired eyes
J Au, S Kancherla, M Hamade, M Mendoza, KC Chan
Quantitative Imaging in Medicine and Surgery, 2020; 10(1):1-14
Quantitative imaging of the clearance systems in the eye and the brain
W Deng, C Liu, C Parra, JR Sims, MA Faiq, A Sainulabdeen, H Song, KC Chan
Progress in Retinal and Eye Research, 2019; 72:100767
Cholinergic nervous system and glaucoma: From basic science to clinical applications
MA Faiq, G Wollstein, JS Schuman, KC Chan.
Scientific Reports, 2019; 9: 14168
Widespread brain reorganization perturbs visuomotor coordination in early glaucoma
V Trivedi, JW Bang, C Parra, MK Colbert, C O’Connell, A Arshad, MA Faiq, IP Conner, MS Redfern, G Wollstein, JS Schuman, R Cham, KC Chan.
Acta Biomaterialia 2019; 94: 219-231.
Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma
KC Chan, Y Yu, SH Ng, HK Mak, YW Yip, Y van der Merwe, T Ren, JS Yung, S Biswas, X Cao, Y Chau, CK Leung.
Frontiers in Neural Circuits, 2019; 13:35
Applications of manganese-enhanced magnetic resonance imaging in ophthalmology and visual neuroscience
W Deng, MA Faiq, C Liu, V Adi, KC Chan.
Neural Regeneration Research, 2019; 14(3):446-449
In vivo imaging of structural, metabolic and functional brain changes in glaucoma
A Kasi, MA Faiq, KC Chan.
Scientific Reports 2018; 8:4643.
Age-related changes in eye, brain and visuomotor behavior in the DBA/2J mouse model of chronic glaucoma
XL Yang, Y van der Merwe, J Sim, C Parra, LC Ho, JS Schuman, G Wollstein, KL Lathrop, KC Chan.
Scientific Reports, 2017; 7:43124
Longitudinal assessments of normal and perilesional tissues in focal brain ischemia and partial optic nerve injury with manganese-enhanced MRI
KC Chan, SS Liu, Y van der Merwe, IY Zhou, SJ Fan, VK Hung, SK Chung, WT Wu, KF So, EX Wu
Experimental Eye Research 2017; 160:85–95
Whole-globe biomechanics using high-field MRI
AP Voorhees, LC Ho, NJ Jan, H Tran, Y van der Merwe, KC Chan*, IA Sigal* (*Co-corresponding authors)
Scientific Reports, 2016; 6:32080.
Non-invasive MRI assessments of tissue microstructures and macromolecules in the eye upon biomechanical or biochemical modulation
LC Ho, IA Sigal, NJ Jan, XL Yang, Y van der Merwe, Y Yu, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman, KC Chan.
Scientific Reports, 2016; 6:31464.
Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma
MC Murphy, IP Conner, C Teng, JD Lawrence, Z Safiullah, B Wang, RA Bilonick, SG Kim, G Wollstein, JS Schuman, KC Chan.
NeuroImage, 2016:125:932-40
Top-down influence on the visual cortex of the blind during sensory substitution
MC Murphy, AC Nau, C Fisher, SG Kim, JS Schuman, KC Chan.
Neural Regeneration Research, 2015; 10(11):1717-19.
Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans
AC Nau, MC Murphy, KC Chan.
Investigative Ophthalmology & Visual Science, 2015; 56(6): 3788-3800.
In vivo evaluation of white matter integrity and anterograde transport in visual system after excitotoxic retinal injury with multimodal MRI and OCT
LC Ho, B Wang, IP Conner, Y van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman, KC Chan.
Investigative Ophthalmology & Visual Science, 2014;55(9):5662-72.
Magic angle-enhanced MRI of fibrous microstructures in sclera and cornea with and without intraocular pressure loading
LC Ho, IA Sigal, NJ Jan, A Squires, Z Tse, EX Wu, SG Kim, JS Schuman, KC Chan.
Investigative Ophthalmology & Visual Science, 2014;55(6):3747-57.
In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI
LC Ho, IP Conner, CW Do, SG Kim, EX Wu, G Wollstein, JS Schuman, KC Chan.