Quantitative imaging of the clearance systems in the eye and the brain.

Selected Publications

Neurotherapeutics, 2021; 18: 1339–1359

Citicoline modulates glaucomatous neurodegeneration through intraocular pressure-independent control

Y van der Merwe, MC Murphy, JR Sims, MA Faiq, XL Yang, LC Ho, IP Conner, Y Yu, CK Leung, G Wollstein, JS Schuman, KC Chan

Frontiers in Medicine 2021; 8:681169

Oral scutellarin treatment ameliorates retinal thinning and visual deficits in experimental glaucoma

J Zhu, A Sainulabdeen, K Akers, V Adi, JR Sims, E Yarsky, Y Yan, Y Yu, H Ishikawa, CK Leung, G Wollstein, JS  Schuman, W Wei, KC Chan

Neural Regeneration Research, 2022; 17(5):937-947

Glymphatic imaging and modulation in the optic nerve

A Kasi, C Liu, MA Faiq, KC Chan

The Neuroscientist (in press)

Visual plasticity in adulthood: Perspectives from Hebbian and homeostatic plasticity

JW Bang, G Hamilton-Fletcher, KC Chan

Investigative Ophthalmology & Visual Science, 2021; 62(10): 21

Diffusion tensor imaging of visual pathway abnormalities in five glaucoma animal models

MK Colbert, LC Ho, Y van der Merwe, XL Yang, GJ McLellan, SA Hurley, AS Field, H Yun, Y Du, JH Fingert, C Parra, MA Faiq, G Wollstein, JS Schuman, KC Chan. 

Role of structural, metabolic, and functional MRI in monitoring visual system impairment and recovery

JR Sims, AM Chen, Z Sun, W Deng, NA Colwell, MK Colbert, J Zhu, A Sainulabdeen, MA Faiq, JW Bang, KC Chan.

Scientific Reports, 2021; 11: 15513

In vivo MRI evaluation of early postnatal development in normal and impaired eyes

J Au, S Kancherla, M Hamade, M Mendoza, KC Chan

Quantitative Imaging in Medicine and Surgery, 2020; 10(1):1-14

Quantitative imaging of the clearance systems in the eye and the brain

W Deng, C Liu, C Parra, JR Sims, MA Faiq, A Sainulabdeen, H Song, KC Chan

Progress in Retinal and Eye Research, 2019; 72:100767

Cholinergic nervous system and glaucoma: From basic science to clinical applications

MA Faiq, G Wollstein, JS Schuman, KC Chan.

Scientific Reports, 2019; 9: 14168

Widespread brain reorganization perturbs visuomotor coordination in early glaucoma

V Trivedi, JW Bang, C Parra, MK Colbert, C O’Connell, A Arshad, MA Faiq, IP Conner, MS Redfern, G Wollstein, JS Schuman, R Cham, KC Chan.

Acta Biomaterialia 2019; 94: 219-231.

Intracameral injection of a chemically cross-linked hydrogel to study chronic neurodegeneration in glaucoma

KC Chan, Y Yu, SH Ng, HK Mak, YW Yip, Y van der Merwe, T Ren, JS Yung, S Biswas, X Cao, Y Chau, CK Leung.

Frontiers in Neural Circuits, 2019; 13:35

Applications of manganese-enhanced magnetic resonance imaging in ophthalmology and visual neuroscience

W Deng, MA Faiq, C Liu, V Adi, KC Chan.

Neural Regeneration Research, 2019; 14(3):446-449

In vivo imaging of structural, metabolic and functional brain changes in glaucoma

A Kasi, MA Faiq, KC Chan.

Scientific Reports, 2017; 7:43124

Longitudinal assessments of normal and perilesional tissues in focal brain ischemia and partial optic nerve injury with manganese-enhanced MRI

KC Chan, SS Liu, Y van der Merwe, IY Zhou, SJ Fan, VK Hung, SK Chung, WT Wu, KF So, EX Wu

Scientific Reports, 2016; 6:32080.

Non-invasive MRI assessments of tissue microstructures and macromolecules in the eye upon biomechanical or biochemical modulation

LC Ho, IA Sigal, NJ Jan, XL Yang, Y van der Merwe, Y Yu, CK Leung, IP Conner, T Jin, EX Wu, SG Kim, G Wollstein, JS Schuman, KC Chan.

Scientific Reports, 2016; 6:31464.

Retinal structures and visual cortex activity are impaired prior to clinical vision loss in glaucoma

MC Murphy, IP Conner, C Teng, JD Lawrence, Z Safiullah, B Wang, RA Bilonick, SG Kim, G Wollstein, JS Schuman, KC Chan.

NeuroImage, 2016:125:932-40

Top-down influence on the visual cortex of the blind during sensory substitution

MC Murphy, AC Nau, C Fisher, SG Kim, JS Schuman, KC Chan.

Neural Regeneration Research, 2015; 10(11):1717-19.

Use of sensory substitution devices as a model system for investigating cross-modal neuroplasticity in humans

AC Nau, MC Murphy, KC Chan.

Investigative Ophthalmology & Visual Science, 2015; 56(6): 3788-3800.

In vivo evaluation of white matter integrity and anterograde transport in visual system after excitotoxic retinal injury with multimodal MRI and OCT

LC Ho, B Wang, IP Conner, Y van der Merwe, RA Bilonick, SG Kim, EX Wu, IA Sigal, G Wollstein, JS Schuman, KC Chan.

Investigative Ophthalmology & Visual Science, 2014;55(6):3747-57.

In vivo assessment of aqueous humor dynamics upon chronic ocular hypertension and hypotensive drug treatment using gadolinium-enhanced MRI

LC Ho, IP Conner, CW Do, SG Kim, EX Wu, G Wollstein, JS Schuman, KC Chan.